Histone Modification: A Mechanism for Regulating Skeletal Muscle Characteristics and Adaptive Changes

Epigenetics is getting increased attention in the analysis of skeletal muscle adaptation to physiological stimuli. In this review, histone modifications muscles and their role regulation characteristics adaptive changes are highlighted. The distribution active modifications, such as H3K4me3 H3 acetylation, largely differs between fast- slow-twitch muscles. It also indicated that transcriptional activity response exercise these types. Histone turnover activated by training leads loosening nucleosomes, which drastically enhances gene responsiveness exercise, indicating transforms chromatin structure an status. Furthermore, play a critical preserving stem cell lineage muscle. Lack lysine-specific demethylase 1 satellite cells promotes differentiation into brown adipocytes during regeneration after injury. H4K20me2, formation heterochromatin, necessary repress MyoD expression cells. These observations indicate modification platform characterizes may be one factors regulating range